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Іndicators of antioxidant status in the serum of piglets when using vitamin E and citrate Zn, Fe and Ge

The period of weaning piglets from sows is a critical stage in the technology of pork production in industrial conditions. The action of stress factors and the formation of free radicals in the body of animals lead to metabolic disorders and the death of pigs in terms of their early weaning. Such a phenomenon in pig breeding requires the use of mineral-compatible and antioxidant preparations for piglets.

Domestic scientists have developed new preparations of vitamin E and citrates Zn, Fe, and Ge, but their effect on the indicators of antioxidant status in the serum of piglets during their early weaning from sows has not been studied.

It has been proven that drinking vitamin E drug and intramuscular administration of a complex of citrates Zn, Fe, and Ge at a dose of 2.5 ml and 3.0 ml per 10 kg body weight for three days before weaning from sows and on the fourth day after weaning. serum superoxide dismutase on the 28th and 35th day of the life of animals. Under the same conditions of use of the studied drugs, a decrease in catalase activity in the serum of animals at 28 and 35 days of life was detected. Proved a tendency to reduce the content of ceruloplasmin in the serum of piglets from research groups.

Key words: superoxide dismutase, catalase, piglets, vitamin E, citrates of Zn, Fe and Ge, ceruloplasmin, antioxidant status.

 

T. Tokarchuk


1. Beaumont, C. Multiple regulatory mechanism act in concert to control ferroportin expression and heme iron recycling by macrophages. Haematologica. 2010, no. 95, pp. 1233–1236.
2. Bhattarai, S., Nielsen, J.P. Early indicators of iron deficiency in large piglets at weaning. J Swine Health Prod. 2015, no. 23, pp. 10–17.
3. Bruininx, E., Swinkels, J., Permentioer, C., Jetten, C., Gentry, J., Schrama, J. Effect of an additional iron injection on growth and humoral immunity of weaning pigs. J Swine Health Prod. 2000, no. 23, pp. 10–17.
4. Dziaman, T., Jurgowiak, M., Olinski, R. Association between body iron stores and level of oxidatively modified DNA bases. Biotechnologia. 2011, no. 2, pp. 159–165.
5. Brun, E. Haemoglobin Status in 3 Weeks Piglets in Herds with Different Strategies for Iron Supply. IPVS Congress, Melbourne, 2000, 62 p.
6. Hansen, S.L., Trakooljul, N., Spears, J.W., Liu, H.C. Age and dietary iron affect expression of genes involved in iron acquisition and homeostasis in young pig. J Nutr. 2010, no. 140, pp. 215–236.
7. Jolliff, J.S., Mahan, D.C. Effect of injected and dietary iron in young pigs on blood hematology and postnatal pig growth performance. J Anim Sci. 2011, no. 89, pp. 4068–4080.
8. Kievit, G.P. Needle-free injection devices versus regular injection techniques for iron supplementation to piglets. Utrecht University Repository. 2012. Retrieved from: https://dspace.library.uu.nl/bitstream/handle/1874/289405/Needle-free_injection_piglets_.
9. Starzynski, R.R., Laarakkers, C.M., Tjalsma, H., Swinkels, D.W., Pieszka, M., Stys, A., Mickiewicz, M., Lipinski, P. Iron supplementation in suckling piglets: How to correct iron deficiency anemia without affecting plasma hepcidin levels. PloSOne. 2013, no. 8(5), e64022. DOI: 10.1371/journal.pone.0064022.
10. Danchuk, V. (2002). Profilaktyka anemii' u novonarodzhenyh porosjat [Prevention of anemia in newborn pigs]. Tvarynnyctvo Ukrai'ny [Animal husbandry of Ukraine], no. 2, pp. 23–25.
11. Vered, P.I., Gerasymenko, V.G., Bitjuc'kyj, V.S. (2005). Obmin zaliza u porosjat pry vykorystanni antyanemichnyh preparativ vitchyznjanogo ta zakordonnogo vyrobnyctva [The exchange of iron in piglets with the use of anti-anamnestic drugs of domestic and foreign production]. Materialy naukovo–praktychnoi' konferencii' «Problemy stanovlennja galuzi tvarynnyctva v suchasnyh umovah» [Materials of the scientific-practical conference "Problems of the formation of livestock industry in modern conditions"]. Vinnytsia, pp. 155–160.
12. Menchikov, L. G., Ignatenko, M. A. Мechanismof drug actionbiological activity of organo germanium compounds (a review). Khimiko-Farmatsevticheskii Zhurnal. 2012, Vol. 46, no. 11, pp. 3–6.
13. Cavaco, L.M. Antimicrob Agents Chemother. 2010, no. 54(9), pp. 3605–3608. DOI: 10.1128/AAC.00058-10.
14. Slifierz, M.J. Zoonoses and Public Health. 2014. DOI: 10.1111/zph.12150.
15. Mogielnicka-Brzozowska, M., Wysocki, P., Strzezek, J., Kordan, W. Zinc-binding proteins from boar seminal plasma - isolation, biochemical characteristics and influence on spermatozoa stored at 4 °C. ActaBiochim Pol. 2011, no. 58, pp. 171–177.
16. Borah, S., Sarmah, B.C., Chakravarty, P., Naskar, S., Dutta, D.J., Kalita, D. Effect of zinc supplementation on serum biochemicals in grower pig. Journal of Applied Animal Research. 2014, no. 42(2), pp. 244­–248.
17. Pamela, J., Fraker, K., Louis, E.K. Reprogramming of the immune system during zinc deficiency. Annual Review of Nutrition. 2004, 24, pp. 277–298.
18. Mocchegiani, E., Mecocci, P. Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects.Exp. Gerontol. 2008, no. 43, pp. 445–51.
19. Borah, S., Sarmah, B. C., Chakravarty, P., Kalita, D. Effect of zinc supplementation on certain enzymes in pigs. Indian Journal of Animal Research. 2012, no. 46 (2), pp. 202–204.
20. Snityns'kyj, V.V., Glozhyk, I.Z., Danchuk, V.V. (2002). Biologichni aspekty vil'noradykal'nogo okyslennja u sil's'kogos-podars'kyh tvaryn u zv’jazku z fiziologichnym stanom i vmistom cynku u racioni [Biological aspects of free radical oxidation in agricultural animals due to the physiological state and zinc content in the diet]. Fiziol. Zhurnal [Physiologist journal], Vol. 48, no. 2, pp. 191–192.
21. Chevari, S., Chaba, I., Sekej, J. (1985). Rol' superoksiddismutazy v okislitel'nyh procecsah kletki i metod oprede-lenija ee v biologicheskih materіalah [The role of superoxide dismutase in the oxidative processes of the cell and the method of its determination in biological materials]. Lab. delo [Laboratory business], no. 11, pp. 678–681.
22. Koroljuk, M.A., Ivanova, A.I., Majorova, I.T., Tokarev, V.E. (1988). Metod opredelenija aktivnosti katalazy [Method for the determination of catalase activity]. Lab. delo [Laboratory business], no. 1, pp. 16–19.
23. Ravin, H.A. Secretion of digestive enzyme by pancreas with minimal transit tissue. J. Lab. Clin. Med. 1961, V. 58, pp. 161–168.
24. Merkur'eva, E.K. (1970). Biometrija v selekcii i genetike sel'skohozjajstvennyh zhivotnyh [Biometrics in breeding and genetics of farm animals]. Moscow, Kolos, 422 p.

 

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BTF №1 2018