The aim of research was to examine the effects of sows' feeding with drug of metabolic – neurotropic action "Hlyutam 1M" during artificial insemination on the metabolic profile of blood and their reproductive ability. Large white sows were placed in individual stalls during their heat period and were artificially inseminated twice with an interval of 18 hours with diluted sperm. It was formed 2 groups of sows with 4 heads. Groups were formed from the sows of medium fatness by groups – analogues. The live weight of sows after the second farrowing ranged from 190–200 kg. Sows of the experimental group were fed with drug "Hlyutam 1M" in a dose of 20 ml of a 1–3 day sexual cycle or three times starting from the day after the first insemination. Group of controlled animals – with 20 ml of saline.

Blood for laboratory tests was taken twice from the sows’ ocular sinus, on 4th and 7th days of the sexual cycle (second and fourth day after the feeding with the drug). From each sow in the morning before feeding the animals it was seized 20 ml of blood. Concentration determination of the studied metabolites in serum of females was performed on the base of biochemical analyzer Sinnova BS3000P, using appropriate methods proposed by RANDOX.

Reproductive capacity of sows was determined according to the data obtained in five experiments conducted at different times of the year in which the experimental animals were fed with the drug by the described scheme. In each of the experiment in the control and experimental groups there were of 15 heads of sows after first and second farrowing (30 heads of sows in total).

Comparative analysis and dynamics of concentration of total protein and albumin in serum of females indicates the trend of intensification of protein metabolism by the drug "Hlyutam 1M" injection in sows.

Between the fourth and seventh day of inseminated sows’ sexual cycle, the energy demands are increasing, which intensify the dissimilation of glucose. This feeding of sows with “Hlyutam 1M” stimulates synthesis and increases the amount of energy twice as blood glucose decreased by 0,37 mmol/l in the group of controlled animals, and by 0,78 mmol/liter in experimental group respectively.

The control and experimental females had almost the same cholesterol levels on the 4th day. On the 7th day of sexual cycle sows of experimental group had no changes in cholesterol level, while sows of controlled group had this level decreased, which contributed to an increase of 15 % difference between the groups.

Urea concentration in the blood of experimental sows was higher on the 4th and 7th day of sexual for 37,0 % (p<0,05) and 34,1 % compared with the controlled group. At the same time, the concentration of urea in the blood of experimental and controlled animals did not change over the 3 days. This may indicate that intensive exchange of amino acids has a prolonged nature due to “Hlyutam 1M”.

Concentration of creatinine at 4th-day of the sexual cycle of the experimental group animals dominated over the controlled group for 19,4 %, but the difference was within the accepted margin of error. On the 7th day of sexual cycle there was no creatinine concentration difference between the experimental and controlled animals. This dynamic indicates an intensification of energy metabolism in the nervous tissue of the brain.

The determined differences in the concentration and dynamics of the studied biochemical components of blood in the controlled and experimental groups of sows must find reflection in their reproductive ability.

Experimental sows (88,3±2,65 %) have higher level of fertility for 11,7 % (p≤0,05), compared with controlled animals (76,6±3,46 %). Multifetation was increased for 1,4 piglets (p≤0,05), large fetation for 5,4 % and the number of stillborn piglets decreased by 25 %.

Key words: sow, the drug "Hlyutam 1M", fertility, large fetation, multi fetation, glucose, protein, urea, creatinine, cholesterol.