In Ukraine there is a number of geochemical provinces, characterized by lack of certain trace elements in soil, forage, animal products and animals. Therefore, feeding farm animals to supplement scarce micronutrients, use various premixes. Low absorption of micronutrients from chlorides, sulfates and oxides increases the risk of environmental pollution by heavy metals because they stand out more from the body than it absorbed.

Therefore, a means of improving the use of micronutrients animal body is to increase the use of livestock minerals in organic form such as Bioplex® foreign production and mixed ligands complex domestic production.

Foreign and domestic scientists proved that salt of micronutrients, particularly sulfate and carbon dioxide, when mixed with vitamins accelerate the destruction of the latter, therefore trace elements introduced into premixes as a chelate compound. Chelated connection element with glycine, methionine or histidine greater in feeding animals than sulfurous compounds.

Thus, the introduction of premixes chelating preparations can be directed to influence the different levels of metabolism in order to maximize the productivity of animals as chelate compounds in animals plays an important role in metabolic processes.

The purpose of research is to experimentally study the formulation of improved zonal premixes for highly productive Holstein cows using foreign production mineral supplements with organic forms of Zn, Cu and domestic mixed ligands complexes of Zn, Cu and Mn with large-scale study of their impact on performance, metabolism, product quality and economic efficiency.

For experiments on the basis of analogues there were selected three groups of Holstein breed cows with 10 heads in each. Cows of different groups in the preparatory and experimental periods were fed with the same diet. The difference was that within 70 days of experimental period, the cows of the 1st control group fed premix was composed by Zinc sulfate, Copper sulfate, Manganese sulfate, Cobalt sulfate, sodium selenite, and cows of the 2nd experimental group – instead of sulphates of Zn, Cu and Mn fed Bioplex® Zn, Cu and Mn, the cows of the 3rd experimental group – mixed ligands complex of Zn, Cu and Mn. Research cows received the same amount of pure Zinc, Copper, Manganese, like cows of the 1st control group.

The use of different sources of trace elements in feeding of Holstein cows within 70 days of lactation, has provided a direct relationship of milk production of these indicators. The highest natural milk yield during the experiment were cows in the experimental group in which diet deficiency of trace elements Zn, Cu and Mn provided by organic compounds of foreign and domestic production. Cows research groups dominated by cows in the control group on average daily yields of natural milk by 3.5 and 3.1 kg, or 10.5 and 9.3 %.

In milk of cows research seen as an unambiguous increase in fat content to 0.05–0.06%. Therefore, preference for average daily milk yield of 4% fat content was also significant compared with the control group and was in the 2nd experimental group 3,5 kg or 12.24 %, in the 3rd experimental group – 3.2 kg or 11.19 % and was significant (P<0,001).

In milk of cows research groups compared with the control, although not too noticeable, but definitely increased protein content (3,13-3,15 against 3.12% in control).

An analysis of the experimental data from cows in the control group on 70 days of the experiment received 2338 kg milk natural fat content, and the 2nd and 3rd research groups – respectively, 245 and 220 kg or 10.5% and 9.3 % greater.

During the period of the experiment, the lowest cost of feed per 1 kg of milk fat 4% share seen in the experimental group of cows were fed rations with trace elements of organic origin. They were on 0,095–0,88 feed units or 12.2 and 11.2 % less than the control group.

The best indicators of milk production of cows and lower the cost of feed per unit of output were obtained in experimental cows due to use of organic origin trace elements, such as Bioplex® Zn, Cu and Mn and mixed ligands complex of Zn, Cu and Mn.

Key words: highly productive cows, ration, premix, minerals, sulfates, mixed ligands complex of Zn, Cu and Mn, milk productivity, feed cost.