Course of various physiological and pathological processes is caused by the individual characteristics of the organism. Free radical oxidation of lipids and proteins in the cells of various organs are occurring with varying intensity. Reactive oxygen can modify the structure of proteins and lipids of biological membranes, which in turn leads to disruption of metabolic processes in cells. Male's sex cells are extremely sensitive to the active forms of Oxegen (AFO) because of grate content of polyunsaturated fatty acids and proteins.

Due to the peculiarities of the chemical structure and the structural organization of proteins, the process of oxidative modification of proteins (OMP) is complex and specific. It is accompanied by violation of skeletal structure of the polypeptide chain or of individual amino acid residues.

The accumulation of protein oxidation is one of the factors which regulate the synthesis and breakdown of proteins, activation of multykatalyzing proteases which are selectively destroying oxidized molecule. In fact, the destruction of oxidized proteins is evaluated as a manifestation of secondary antioxidant in tissues.

OMP is one of the earliest and most reliable indicator of lesions in free radical pathology, as well as one of the markers of oxidative stress. In this regard, the use of drugs with antioxidant and metabolic properties is promising direction in biology. These includes biologically active drug with vitamins and minerals "Multybakterin."

For research there were used boar-sires of Large White breeds and synthetic lines SS23. The material for the study is semen. The intensity of OMP was evaluated by content aldehidnitrophenilhydrazones and ketonitrophenilhydrazones (ADNPH and KDNPH). The content of middle mass molecules (MMM) was determined by screening of autoimmune processes assessed by the content of circulating immune complexes (CIC). Experimental datas were processed by conventional methods of statistics.

Using of "Multybakterine" for feeding increases the total protein in semen of boars. So, on the 15th day of the experiment the protein contents of sperm plasma of purebred boars increased by 23.6 %, in synthetic line animals - by 24.8 % as compared with the control. A similar trend is evident in sperm cell's plazma. Boar-sires ejaculate of both breeds consisted with oxidation products of proteins which reacted with 2,4-dynitrophenilhidrazyne. The basic amount formed dynitrophenilhidrazones belongs to aldehidogenic and ketogenic neutral.

Against the background of compound feeding semen plasma of boars of both breeds had a tendency to decrease in the concentration of KDNPH neutral. The number of these OMP products in semen plasma of sires Large White breed decreased by 23.2 % and in animals of synthetic line by 10.1 % compared to rates in control. This marked the likely reduction ADNFH neutral in purebred boars 2.0 x animals synthetic line SS23 - 1.6 times compared with the control. On the 15th day of the experiment the concentration of aldehidogenic and ketogenic by main character boar sperm plasma studied species was actually 2 times lower in comparison with the original neutral. By the end of the experiment the number of OMP products main character continued to decline relative to carbonyl compounds neutral.

Number of ADNPH by main character in sperm cell plazma of Large White breed animals for two weeks using "Multybakterine" did not change. However, the significant reduction of all factions oxidized proteins compared with controls were shown by the end of the experiment revealed. Fluctuating contents of various products OMP have their own characteristics, which are probably due to the conditions of their formation. For example, some OMP products are formed by direct interaction with protein molecules AFO, while others are formed by the interaction of the products of lipid peroxidation and glikooksydation.

The degree of endogenous intoxication in animals by the use of "Multybakterine" was studied based on the content of MMM for 254 nm and 280 nm. The results showed that feeding multicomponent drug for boar-sires help to reduce MMM in their semen. So, on the 15th day of the experiment the number of sperm plasma MMM280 of purebred animals is reduced by 11.8 % and in animals synthetic line by 18.8 % compared with the control. On the 30th day the level of middle molekular peptides in boars research groups continued to decline to 41.2 % and 37.5 % respectively. The concentration of MMM in sperm sires slightly higher compared to plasma sperm.

Functionality of humoral immunity in the boars bodies by using of "Multybakterine" was assessed by сirculating immune complexes (CIC). Under physiological conditions, the formation and presence of CIC in biological fluids is one of the manifestations of the immune response to antigens and it is an important factor that provides immunity. CIC concentration in plasma and semen plazma of boar-sires of large white breed slightly higher compared with animals synthetic line. Against the background of feeding the drug "Multybakterine" is is shown the tends to decrease circulating immune complexes in the ejaculate studied groups of animals.

Feeding "Multybakterine" for boar-sires improves the adaptation of the organism in industrial pig. In particular, it is showm the decrease of concentration of products of oxidative modification of proteinsthe in semen of studied animals.

Key words: boars, semen, oxidative modification of proteins, molecules mass medium, circulating immune complexes.